Microsoft's framework for multi-agent AI applications.
Agent frameworks & SDKsopen-source
AutoGen vs Mastra
Verdict: in our “Best for multi-agent orchestration” ranking, AutoGen ranks #3 and Mastra ranks #4. The table compares their verified basics; how we rank.
| Feature | AutoGen | Mastra |
|---|---|---|
| What it is | Microsoft's framework for multi-agent AI applications. | TypeScript framework for AI agents and workflows. |
| Category | Agent frameworks & SDKs | Agent frameworks & SDKs |
| Pricing model | open-source | open-source |
| Integrations | API | API, MCP |
| Self-hostable | Yes | Yes |
| Open-source repo | microsoft/autogen | mastra-ai/mastra |
| Rank in “Best for multi-agent orchestration” | #3 | #4 |
| StackRank score | Not yet benchmarked | Not yet benchmarked |
| Last verified | Oct 14, 2026 | Oct 14, 2026 |
Try them
TypeScript framework for AI agents and workflows.
Agent frameworks & SDKsopen-source